|
CAS No.: |
81810-66-4 |
Molecular weight |
306.315 |
|
Density |
1.2±0.1g/cm3 |
Boiling point |
576.9±60.0°C at 760 mmHg |
|
Molecular formula |
C18H14N2O3 |
Melting point |
183-188oC |
|
MSDS |
N/A |
Flash point |
302.7±32.9 °C |
Uses:
Quinocetone is a powerful synthetic antibacterial agent that can be used to improve the feed efficiency of animal feed and control dysentery.
Function:
The mechanism of action of quinocetone is mainly to promote the secondary increase of assimilation and growth hormone, and accelerate the growth of animals. And by effectively inhibiting the synthesis of bacterial DNA, it inhibits the growth and reproduction of pathogenic microorganisms in the digestive tract. For poultry, especially young poultry, it has remarkable antibacterial, antidiarrheal and growth-promoting effects.
Quinocetone, as a new drug feed additive, has the functions of disease prevention and growth promotion. Its drug effect, toxicity and metabolism in the body are completely different from olaquindox and Rouduojia. A series of toxicity tests with quinocetone pilot products show that the oral LD50 of mice is 14398 mg/kg body weight, and the oral LD50 of rats is 8179 mg/kg body weight. The toxicity is only 1/4 of that of olaquindox, which is almost non-toxic . After nearly 10,000 chickens and more than 250 pigs' pharmacological and clinical verification experiments, it was proved that quinocetone has significant antibacterial and growth-promoting effects. For more than ten years, quinocetone has been tested in some farms and farmers in more than ten provinces and cities in China. Its effect of disease prevention and growth promotion is good, and it is safe and has no side effects.
The aberration test of quinocetone on the sperm of mice was administered by intragastric administration at doses of 1/20, 1/10, and 1/5 LD50, once every day for a total of 5 days, and 30 days after the last administration. Microscopic examination of sperm distortion was performed. The results showed that quinocetone did not cause a significant increase in the abnormality rate of sperm in mice.
Carcinogenicity test of long-term feeding quinocetone to mice, after adding 75, 150, 300 mg/kg to the feed of mice for 20 months, after clinical examination, blood examination, biochemical examination and pathological examination, the results were not inconclusive. Quinocetones were found to be carcinogenic.
Quinocetone has a certain effect on disease prevention (low mortality and morbidity), growth promotion and improvement of feed utilization. Subchronic toxic effects of a new veterinary drug quinocetone in rats. Tests have shown that the maximum no-effect dose of quinocetone to rats is 32.8mg/(kg body weight·d).